C19orf57

Across TCGA pan-cancer cohorts, C19orf57 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated C19orf57 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher C19orf57 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C19orf57 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

KIRP, HNSC, and ACC are the cancer types where C19orf57 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.728	0.911	<.001	134	view →
HNSC	OS	Median	All	0.803	0.697	<.001	130	view →
ACC	DFS	Median	All	0.417	0.742	<.001	83	view →
KICH	DFS	Tertile	III,IV	0.240	1.000	.002	82	view →
UCS	OS	Tertile	II,III,IV	0.831	0.388	.001	56	view →
UCEC	DFS	Median	All	0.782	0.890	<.001	52	view →
CESC	DFS	Median	All	0.796	0.677	.010	34	view →
MESO	OS	Median	All	0.447	0.647	.002	33	view →
SKCM	OS	Tertile	IV	0.820	0.269	.005	23	view →
STAD	OS	Median	III,IV	0.610	0.425	.019	21	view →
LIHC	OS	Quartile	II,III,IV	0.356	0.745	.003	21	view →
LGG	DFS	Quartile	All	0.784	0.894	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

C19orf57–KIRP (DFS)

Open the KIRP breakdown →