C19orf57

Across TCGA cell cohorts, C19orf57 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible C19orf57-associated genes across cancer lineages are NTSR2, BPIFA1, and SIGLEC8. Each is linked with C19orf57 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf57-to-partner and partner-to-C19orf57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTSR2 grouped by C19orf57-low versus C19orf57-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf57→partner) and Y-score (partner→C19orf57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NTSR2 →	+0.082	+3.793	<.001	.007	3	1
LARGE_INTESTINE	BPIFA1 →	+0.157	+4.688	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
SKIN	AMELY →	+0.016	+4.415	.001	.007	3	1
CNS	C8orf74 →	+0.034	+4.315	<.001	.006	3	1
CNS	LIPM →	+0.064	+4.643	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

NTSR2 by C19orf57 expression — LARGE_INTESTINE

Explore this box plot interactively →