C19orf48

Across TCGA patient cohorts, C19orf48 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf48-associated genes across cancer lineages are Myosin-IIa_pS1943, Annexin-1, and Shc_pY317. Each is linked with C19orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf48-to-partner and partner-to-C19orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by C19orf48-low versus C19orf48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf48→partner) and Y-score (partner→C19orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.227	+3.335	.035	.005	3	1
UCEC	Annexin-1 →	+0.644	+3.019	.019	.019	3	1
UCEC	Shc_pY317 →	-0.216	-3.321	.006	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.779	+3.321	.012	.010	3	1
UCEC	Lck →	+0.306	+3.321	.003	.010	1	1
UCEC	MEK1_p_S217_S221 →	-0.388	-3.321	.006	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Myosin-IIa_pS1943 by C19orf48 expression — UCEC

Explore this box plot interactively →