C19orf44

Across TCGA pan-cancer cohorts, C19orf44 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C19orf44 data layer compared with 6 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher C19orf44 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C19orf44 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

LGG, KIRC, and HNSC are the cancer types where C19orf44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.266	0.510	<.001	52	view →
KIRC	DFS	Tertile	All	0.768	0.499	<.001	39	view →
HNSC	DFS	Tertile	IV	0.471	0.266	.004	30	view →
UCS	DFS	Median	IV	0.850	0.475	.023	30	view →
ACC	DFS	Quartile	All	0.342	0.837	<.001	29	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.700	.001	25	view →
CHOL	OS	Tertile	All	1.000	0.149	.005	21	view →
ESCA	DFS	Quartile	All	1.000	0.179	<.001	18	view →
KICH	OS	Tertile	All	0.530	0.939	.010	18	view →
SCLC	DFS	Tertile	II,III,IV	1.000	0.269	.006	16	view →
PAAD	DFS	Tertile	All	0.442	0.169	.002	16	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C19orf44–LGG (DFS)

Open the LGG breakdown →