C19orf25

Across TCGA patient cohorts, C19orf25 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf25-associated genes across cancer lineages are RNU6-259P, RNA5SP407, and RNA5SP518. Each is linked with C19orf25 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf25-to-partner and partner-to-C19orf25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-259P grouped by C19orf25-low versus C19orf25-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf25→partner) and Y-score (partner→C19orf25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-259P →	+0.391	+7.924	<.001	.008	3	1
LUSC	RNA5SP407 →	+0.633	+7.924	<.001	.008	3	1
LUSC	RNA5SP518 →	+0.358	+7.924	<.001	.008	3	1
LUSC	RNU6-1270P →	+0.388	+7.924	<.001	.008	3	1
UCEC	MIR7702 →	+1.269	+8.060	<.001	<.001	3	1
UCEC	RNU6-1082P →	+0.860	+5.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

RNU6-259P by C19orf25 expression — LUSC

Explore this box plot interactively →