C19orf18

Across TCGA patient cohorts, C19orf18 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf18-associated genes across cancer lineages are PCNA, TAZ, and ATM. Each is linked with C19orf18 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf18-to-partner and partner-to-C19orf18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by C19orf18-low versus C19orf18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf18→partner) and Y-score (partner→C19orf18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.262	+3.169	.027	.020	3	1
UCEC	TAZ →	-0.163	-3.169	.036	.020	3	1
UCEC	ATM →	-0.506	-3.169	.042	.020	3	1
UCEC	Cyclin-E2 →	+0.225	+3.169	.015	.020	3	1
SKCM	eEF2K →	+0.433	+2.824	.042	.036	2	1
UCEC	p62 Lck ligand →	+0.505	+3.009	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PCNA by C19orf18 expression — UCEC

Explore this box plot interactively →