C19orf12

Across TCGA patient cohorts, C19orf12 mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf12-associated genes across cancer lineages are MIR4511, RNU4-70P, and MT-TS1. Each is linked with C19orf12 in more than 2 cancer types. Because this analysis shows association rather than direction, both C19orf12-to-partner and partner-to-C19orf12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4511 grouped by C19orf12-low versus C19orf12-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf12→partner) and Y-score (partner→C19orf12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4511 →	+0.574	+4.287	<.001	.008	3	3
HNSC	RNU4-70P →	+0.643	+7.954	<.001	.008	3	2
COAD	MT-TS1 →	+0.566	+5.693	.001	.003	3	2
COAD	MIR3140 →	+2.068	+5.602	<.001	.004	3	2
UCEC	MIR1266 →	+0.228	+3.186	<.001	.001	3	2
UCEC	RN7SKP188 →	+0.115	+2.912	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

MIR4511 by C19orf12 expression — LUSC

Explore this box plot interactively →