C18orf54

Across TCGA patient cohorts, C18orf54 mutation is significantly associated with the RNA expression of many other genes, with 1,423 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C18orf54-associated genes across cancer lineages are RPSAP60, RPS27AP14, and SLC25A31. Each is linked with C18orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C18orf54-to-partner and partner-to-C18orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP60 grouped by C18orf54-low versus C18orf54-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C18orf54→partner) and Y-score (partner→C18orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPSAP60 →	+0.295	+4.129	<.001	.004	3	2
COAD	RPS27AP14 →	+0.129	+4.418	.002	.008	3	2
UCEC	SLC25A31 →	+0.082	+1.804	.002	.003	3	2
BLCA	HNRNPH3P1 →	+0.098	+5.411	<.001	.005	3	2
SKCM	SNORD116-10 →	+0.216	+4.302	<.001	.007	3	2
COAD	RPA3P1 →	+0.633	+3.818	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,423 associations by consensus.

RPSAP60 by C18orf54 expression — COAD

Explore this box plot interactively →