C17orf80

Across TCGA patient cohorts, C17orf80 mutation is significantly associated with the RNA expression of many other genes, with 1,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf80-associated genes across cancer lineages are PDCD2L, CAPN10, and L3MBTL2. Each is linked with C17orf80 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf80-to-partner and partner-to-C17orf80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD2L grouped by C17orf80-low versus C17orf80-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf80→partner) and Y-score (partner→C17orf80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD2L →	+0.494	+3.208	.002	.009	3	2
SKCM	CAPN10 →	+0.489	+3.198	.003	.009	3	2
UCEC	L3MBTL2 →	+0.362	+2.947	.001	<.001	3	2
UCEC	TRMU →	+0.487	+3.938	<.001	<.001	3	2
UCEC	VPS18 →	+0.643	+3.721	<.001	<.001	3	2
UCEC	PLEKHJ1 →	+0.594	+3.119	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,035 associations by consensus.

PDCD2L by C17orf80 expression — SKCM

Explore this box plot interactively →