C17orf80

Across TCGA pan-cancer cohorts, C17orf80 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated C17orf80 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher C17orf80 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C17orf80 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

LIHC, KIRC, and ACC are the cancer types where C17orf80 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.447	0.633	<.001	110	view →
KIRC	OS	Tertile	All	0.728	0.574	<.001	80	view →
ACC	DFS	Tertile	II,III,IV	0.405	0.808	<.001	39	view →
THYM	DFS	Tertile	All	0.885	0.592	<.001	35	view →
BRCA	DFS	Tertile	III,IV	0.940	0.781	.001	28	view →
COAD	OS	Median	All	0.887	0.717	.002	27	view →
LGG	OS	Quartile	All	0.756	0.941	.004	26	view →
LUSC	DFS	Quartile	III,IV	0.368	0.754	.001	23	view →
MESO	OS	Quartile	IV	0.156	0.817	.006	21	view →
CESC	DFS	Quartile	All	0.623	0.821	.005	18	view →
UCS	OS	Quartile	II,III,IV	0.728	0.269	.021	16	view →
HNSC	OS	Tertile	III,IV	0.390	0.706	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

C17orf80–LIHC (DFS)

Open the LIHC breakdown →