C17orf80

Across TCGA patient cohorts, C17orf80 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C17orf80-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and MEK1. Each is linked with C17orf80 in more than 1 cancer types. Because this analysis shows association rather than direction, both C17orf80-to-partner and partner-to-C17orf80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by C17orf80-low versus C17orf80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C17orf80→partner) and Y-score (partner→C17orf80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.140	-2.700	.001	.005	3	2
UCEC	INPP4B →	-0.239	-3.169	.048	.018	3	2
UCEC	MEK1 →	+0.327	+2.321	.017	.005	3	2
UCEC	ATM →	-0.373	-1.415	.028	.046	3	2
UCEC	ERK2 →	+0.181	+2.222	.012	.010	3	1
UCEC	ACVRL1 →	-0.106	-2.308	.038	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

A-Raf_pS299 by C17orf80 expression — UCEC

Explore this box plot interactively →