C16orf91

Across TCGA patient cohorts, C16orf91 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf91-associated genes across cancer lineages are EEF1E1-BLOC1S5, NMBR-AS1, and RPL9P15. Each is linked with C16orf91 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf91-to-partner and partner-to-C16orf91 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by C16orf91-low versus C16orf91-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf91→partner) and Y-score (partner→C16orf91) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	EEF1E1-BLOC1S5 →	+0.033	+4.384	<.001	.008	3	2
CESC	NMBR-AS1 →	+0.166	+4.196	<.001	.003	3	1
CESC	RPL9P15 →	+0.036	+4.384	<.001	.008	3	1
CESC	RPS27P12 →	+0.153	+4.384	<.001	.008	3	1
CESC	RN7SL250P →	+0.497	+3.653	.008	.009	3	1
CESC	RN7SKP260 →	+0.292	+5.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

EEF1E1-BLOC1S5 by C16orf91 expression — CESC

Explore this box plot interactively →