Across TCGA pan-cancer cohorts, C16orf82 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of C16orf82’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where C16orf82 RNA is repressed in tumor relative to normal tissue. In most cancer types C16orf82 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and BLCA are the cancer types where C16orf82 tumor–normal differential expression is most reproducible.