C16orf72

Across TCGA patient cohorts, C16orf72 mutation is significantly associated with the RNA expression of many other genes, with 559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C16orf72-associated genes across cancer lineages are SENP3-EIF4A1, VMO1, and FAM177A1. Each is linked with C16orf72 in more than 1 cancer types. Because this analysis shows association rather than direction, both C16orf72-to-partner and partner-to-C16orf72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3-EIF4A1 grouped by C16orf72-low versus C16orf72-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C16orf72→partner) and Y-score (partner→C16orf72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SENP3-EIF4A1 →	+0.104	+3.558	.003	.002	3	2
UCEC	VMO1 →	+0.903	+2.700	.002	.006	3	2
UCEC	FAM177A1 →	+0.388	+2.601	.002	.006	3	1
UCEC	AP1S3 →	+0.724	+3.584	<.001	.002	3	1
UCEC	TMEM251 →	+0.521	+2.823	.005	.001	3	1
UCEC	GBP5 →	+0.884	+3.475	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

SENP3-EIF4A1 by C16orf72 expression — UCEC

Explore this box plot interactively →