C15orf65

Across TCGA pan-cancer cohorts, C15orf65 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C15orf65’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where C15orf65 RNA is repressed in tumor relative to normal tissue. In most cancer types C15orf65 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where C15orf65 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C15orf65 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.124	<.001	11	view →
THCA	Male	III,IV	−1.020	<.001	10	view →
LIHC	Male	III,IV	+0.848	<.001	8	view →
KIRC	Male	II,III,IV	−0.659	<.001	8	view →
LUSC	Male	All	−0.496	<.001	6	view →
BRCA	All	All	+0.392	<.001	6	view →
CHOL	Female	All	+2.716	<.001	5	view →
COAD	Female	All	−0.715	.008	4	view →
READ	Female	All	−0.960	.009	2	view →
PRAD	All	All	+0.617	<.001	2	view →
BLCA	All	All	+0.486	.045	2	view →
STAD	Male	III,IV	−0.803	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C15orf65–KICH

Open the KICH breakdown →