C15orf40

Across TCGA patient cohorts, C15orf40 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C15orf40-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with C15orf40 in more than 1 cancer types. Because this analysis shows association rather than direction, both C15orf40-to-partner and partner-to-C15orf40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by C15orf40-low versus C15orf40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C15orf40→partner) and Y-score (partner→C15orf40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.511	+2.999	.003	.035	3	1
UCEC	EGFR_pY1068 →	-0.312	-3.321	.010	.010	3	1
UCEC	A-Raf_pS299 →	-0.141	-3.584	.014	.002	3	1
UCEC	IGFBP2 →	-0.877	-3.169	.005	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-2.446	.019	.020	3	1
UCEC	MSH6 →	-0.460	-2.999	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by C15orf40 expression — UCEC

Explore this box plot interactively →