C15orf40

Across TCGA pan-cancer cohorts, C15orf40 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of C15orf40’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C15orf40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C15orf40 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where C15orf40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C15orf40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.978	<.001	12	view →
THCA	Male	All	−0.344	<.001	10	view →
LIHC	Male	All	+0.757	<.001	9	view →
KICH	Male	All	−0.736	<.001	9	view →
KIRC	Male	All	−0.238	<.001	6	view →
CHOL	All	All	+1.495	<.001	5	view →
STAD	Male	II,III,IV	+0.465	.003	4	view →
BLCA	All	All	+0.313	.016	4	view →
LUSC	All	All	+0.292	<.001	4	view →
BRCA	Female	All	−0.239	<.001	4	view →
UCEC	All	All	−0.409	.002	2	view →
KIRP	All	All	−0.262	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

C15orf40–HNSC

Open the HNSC breakdown →