C12orf75

Across TCGA pan-cancer cohorts, C12orf75 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C12orf75 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C12orf75 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf75 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where C12orf75 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.499	0.979	.020	11	view →
LUAD	DFS	Quartile	II,III,IV	0.823	0.270	.004	10	view →
PDAC	OS	Quartile	All	0.880	0.750	.019	7	view →
CCRCC	DFS	Median	II,III,IV	0.589	0.822	.030	6	view →
LSCC	DFS	Tertile	All	0.909	1.000	.026	2	view →
GBM	DFS	Median	All	0.831	0.659	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C12orf75–HNSC (OS)

Open the HNSC breakdown →