C12orf75

Across TCGA pan-cancer cohorts, C12orf75 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C12orf75’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C12orf75 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf75 is over-expressed in tumor, although a few such as LUAD and OV show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where C12orf75 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf75 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.740	<.001	11	view →
LUAD	All	III,IV	−0.725	<.001	9	view →
LSCC	All	II,III,IV	+0.317	.003	4	view →
OV	All	All	−0.867	.004	2	view →
PDAC	All	All	−0.275	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C12orf75–HNSC

Open the HNSC breakdown →