Across TCGA pan-cancer cohorts, C12orf71 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C12orf71’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where C12orf71 RNA is repressed in tumor relative to normal tissue. In most cancer types C12orf71 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

BRCA, LUAD, and THCA are the cancer types where C12orf71 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf71 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.318	<.001	6	view →
LUAD	All	All	−0.197	.005	5	view →
THCA	All	All	−0.116	<.001	4	view →
KIRP	All	All	−0.091	.022	3	view →
KICH	All	All	−0.100	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: C12orf71 RNA expression & survival · all C12orf71 data types