C12orf65

Across TCGA patient cohorts, C12orf65 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf65-associated genes across cancer lineages are DHDDS, TYRL, and ETFA. Each is linked with C12orf65 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf65-to-partner and partner-to-C12orf65 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHDDS grouped by C12orf65-low versus C12orf65-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf65→partner) and Y-score (partner→C12orf65) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHDDS →	+0.464	+3.332	.003	.005	3	1
UCEC	TYRL →	+0.135	+3.356	<.001	.005	3	1
UCEC	ETFA →	+0.785	+3.201	<.001	.009	3	1
UCEC	MIR8087 →	+0.434	+2.550	.005	.006	3	1
UCEC	GATD3B →	+0.793	+3.332	<.001	.005	3	1
COAD	OR4C46 →	+0.179	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

DHDDS by C12orf65 expression — UCEC

Explore this box plot interactively →