C12orf57

Across TCGA patient cohorts, C12orf57 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf57-associated genes across cancer lineages are SEPTIN14P1, RNU6-536P, and RNU6-1066P. Each is linked with C12orf57 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf57-to-partner and partner-to-C12orf57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P1 grouped by C12orf57-low versus C12orf57-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf57→partner) and Y-score (partner→C12orf57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SEPTIN14P1 →	+0.082	+5.539	<.001	.004	3	2
CESC	RNU6-536P →	+0.276	+5.010	.001	.009	3	1
CESC	RNU6-1066P →	+0.398	+5.418	<.001	.005	3	1
CESC	S100A7P1 →	+0.129	+5.969	<.001	.002	3	1
CESC	C7orf66 →	+0.083	+5.539	<.001	.004	3	1
CESC	RNU6-246P →	+0.603	+5.306	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

SEPTIN14P1 by C12orf57 expression — CESC

Explore this box plot interactively →