C12orf57

Across TCGA pan-cancer cohorts, C12orf57 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated C12orf57 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C12orf57 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf57 expression acts as an unfavorable survival marker, although some lineages such as PAAD and MESO show a favorable association.

ACC, UVM, and KIRP are the cancer types where C12orf57 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.467	0.778	<.001	99	view →
UVM	OS	Tertile	All	0.358	0.895	<.001	98	view →
KIRP	DFS	Median	All	0.770	0.980	.002	45	view →
PAAD	OS	Tertile	All	0.584	0.265	.001	31	view →
UCS	OS	Median	IV	0.404	0.752	.013	30	view →
DLBC	OS	Median	II,III,IV	0.299	1.000	.010	26	view →
MESO	DFS	Tertile	All	0.659	0.218	.019	21	view →
READ	OS	Median	II,III,IV	0.811	0.981	.014	17	view →
LIHC	OS	Median	All	0.706	0.854	.001	17	view →
CHOL	DFS	Quartile	All	0.278	0.819	.035	9	view →
COAD	DFS	Quartile	IV	0.304	0.696	.010	9	view →
LUAD	OS	Median	IV	0.323	0.681	.041	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

C12orf57–ACC (DFS)

Open the ACC breakdown →