Across TCGA patient cohorts, C12orf56 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf56-associated genes across cancer lineages are PI3K-p85, Src_pY416, and 14-3-3_beta. Each is linked with C12orf56 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf56-to-partner and partner-to-C12orf56 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf56→partner) and Y-score (partner→C12orf56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PI3K-p85 →	+0.281	+3.321	.010	.010	3	1
SKCM	Src_pY416 →	+0.482	+3.169	.002	.018	3	1
UCEC	14-3-3_beta →	-0.085	-2.432	.034	.018	3	1
UCEC	EGFR_pY1068 →	-0.276	-2.584	.006	.010	3	1
UCEC	ERK2 →	+0.210	+3.087	.006	<.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.434	+1.884	.033	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

C12orf56 survival (RNA) · tumor vs normal (RNA) · all C12orf56 data types