Across TCGA pan-cancer cohorts, C12orf56 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of C12orf56’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where C12orf56 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf56 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.
LUSC, HNSC, and THCA are the cancer types where C12orf56 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf56 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.