C12orf50

Across TCGA pan-cancer cohorts, C12orf50 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated C12orf50 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher C12orf50 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C12orf50 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

KICH, BRCA, and UCEC are the cancer types where C12orf50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.025	0.904	<.001	36	view →
BRCA	OS	Median	All	0.514	0.963	.001	24	view →
UCEC	OS	Median	II,III,IV	0.893	0.456	.029	20	view →
COAD	DFS	Median	II,III,IV	0.193	0.779	.001	12	view →
ESCA	DFS	Median	II,III,IV	0.082	0.495	.002	6	view →
SKCM	OS	Median	III,IV	0.573	0.845	.048	3	view →
GBM	OS	Median	All	1.000	0.257	.040	2	view →
LUSC	OS	Median	II,III,IV	0.142	0.417	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

C12orf50–KICH (DFS)

Open the KICH breakdown →