C12orf50

Across TCGA patient cohorts, C12orf50 mutation is significantly associated with the RNA expression of many other genes, with 3,742 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf50-associated genes across cancer lineages are PANK4, WDR4, and APEH. Each is linked with C12orf50 in more than 2 cancer types. Because this analysis shows association rather than direction, both C12orf50-to-partner and partner-to-C12orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PANK4 grouped by C12orf50-low versus C12orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf50→partner) and Y-score (partner→C12orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PANK4 →	+0.252	+2.223	.004	.001	3	3
UCEC	WDR4 →	+0.419	+1.601	<.001	.001	3	3
UCEC	APEH →	+0.369	+2.695	.001	<.001	3	3
UCEC	CDT1 →	+0.967	+3.354	<.001	<.001	3	3
UCEC	CHAF1A →	+0.857	+3.343	<.001	<.001	3	3
UCEC	FEN1 →	+0.692	+1.797	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,742 associations by consensus.

PANK4 by C12orf50 expression — UCEC

Explore this box plot interactively →