C12orf50

Across TCGA patient cohorts, C12orf50 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf50-associated genes across cancer lineages are ACC1, Cyclin-E2, and ACC_pS79. Each is linked with C12orf50 in more than 2 cancer types. Because this analysis shows association rather than direction, both C12orf50-to-partner and partner-to-C12orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by C12orf50-low versus C12orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf50→partner) and Y-score (partner→C12orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.359	+3.100	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.105	+1.161	.034	.032	3	3
SKCM	ACC_pS79 →	+0.224	+2.906	.013	.001	3	2
UCEC	FASN →	+0.324	+1.432	.005	.005	3	2
UCEC	p27_pT157 →	-0.037	-1.401	.027	.040	3	2
UCEC	p70-S6K →	+0.119	+1.267	.035	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ACC1 by C12orf50 expression — UCEC

Explore this box plot interactively →