C12orf50

Across TCGA cell cohorts, C12orf50 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,304 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C12orf50-associated GO terms across cancer lineages are Negative regulation of telomere maintenance, Regulation of myoblast fusion, and Negative regulation of myoblast fusion. Each is linked with C12orf50 in more than 5 cancer types. Because this analysis shows association rather than direction, both C12orf50-to-partner and partner-to-C12orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere maintenance grouped by C12orf50-low versus C12orf50-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf50→partner) and Y-score (partner→C12orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of telomere maintenance →	+0.052	+0.033	.006	.008	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.131	+0.061	<.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.147	+0.061	<.001	.005	3	5
LUNG_SCLC	Regulation of post-translational protein modification →	+0.042	+0.106	<.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic translation →	+0.107	+0.047	<.001	.009	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.109	+0.039	<.001	.008	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,304 associations by consensus.

Negative regulation of telomere maintenance by C12orf50 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →