C12orf45

Across TCGA patient cohorts, C12orf45 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible C12orf45-associated genes across cancer lineages are RNA5SP424, RNU4-26P, and RNA5SP183. Each is linked with C12orf45 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf45-to-partner and partner-to-C12orf45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP424 grouped by C12orf45-low versus C12orf45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf45→partner) and Y-score (partner→C12orf45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP424 →	+0.677	+5.242	<.001	.007	3	2
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	2
BLCA	RNA5SP183 →	+0.519	+5.177	<.001	.007	3	1
BLCA	RNU6-1188P →	+0.659	+5.411	<.001	.005	3	1
BLCA	RNU6-694P →	+0.294	+6.289	<.001	.001	3	1
BLCA	RNU4-9P →	+0.303	+5.685	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

RNA5SP424 by C12orf45 expression — UCEC

Explore this box plot interactively →