C12orf42

Across TCGA patient cohorts, C12orf42 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf42-associated genes across cancer lineages are C-Raf, Ku80, and Src. Each is linked with C12orf42 in more than 2 cancer types. Because this analysis shows association rather than direction, both C12orf42-to-partner and partner-to-C12orf42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by C12orf42-low versus C12orf42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf42→partner) and Y-score (partner→C12orf42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.248	+3.000	<.001	<.001	3	3
UCEC	Ku80 →	+0.240	+2.100	.008	.003	3	2
UCEC	Src →	-0.226	-2.295	.004	.033	3	2
UCEC	ATM →	-0.601	-3.459	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.167	-3.446	.003	.005	3	2
SKCM	PREX1 →	-0.444	-3.000	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

C-Raf by C12orf42 expression — UCEC

Explore this box plot interactively →