C12orf42

Across TCGA pan-cancer cohorts, C12orf42 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of C12orf42’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C12orf42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C12orf42 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where C12orf42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C12orf42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.249	<.001	12	view →
LUAD	All	All	+0.320	<.001	7	view →
LUSC	Male	All	+0.175	<.001	5	view →
BRCA	All	II,III,IV	+0.077	.002	4	view →
KIRC	All	All	+0.037	.003	4	view →
STAD	All	All	+0.223	.005	3	view →
THCA	All	All	−0.108	.010	2	view →
LIHC	All	All	+0.050	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

C12orf42–HNSC

Open the HNSC breakdown →