C12orf40

Across TCGA pan-cancer cohorts, C12orf40 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C12orf40 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher C12orf40 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C12orf40 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

THCA, ESCA, and SKCM are the cancer types where C12orf40 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.255	0.954	<.001	20	view →
ESCA	OS	Median	II,III,IV	0.255	0.706	<.001	18	view →
SKCM	DFS	Median	III,IV	1.000	0.571	.015	8	view →
LUAD	DFS	Median	IV	0.671	0.893	.019	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.912	0.623	.025	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C12orf40–THCA (OS)

Open the THCA breakdown →