C12orf29

Across TCGA patient cohorts, C12orf29 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C12orf29-associated genes across cancer lineages are p21, GATA6, and JNK_pT183_Y185. Each is linked with C12orf29 in more than 1 cancer types. Because this analysis shows association rather than direction, both C12orf29-to-partner and partner-to-C12orf29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by C12orf29-low versus C12orf29-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C12orf29→partner) and Y-score (partner→C12orf29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.168	+3.169	.045	.019	3	2
UCEC	GATA6 →	-0.168	-3.321	.016	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.228	-3.321	.001	.010	3	1
UCEC	Ku80 →	+0.261	+2.820	.011	.035	3	1
UCEC	Notch1 →	+0.246	+2.472	<.001	.010	3	1
UCEC	p27_pT198 →	+0.125	+2.115	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p21 by C12orf29 expression — UCEC

Explore this box plot interactively →