C11orf86

Across TCGA patient cohorts, C11orf86 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf86-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, ATM, and Notch1. Each is linked with C11orf86 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf86-to-partner and partner-to-C11orf86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by C11orf86-low versus C11orf86-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf86→partner) and Y-score (partner→C11orf86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.634	+3.000	.031	.037	3	1
UCEC	ATM →	-0.769	-3.000	.003	.037	3	1
UCEC	Notch1 →	+0.261	+3.000	.001	.037	2	1
UCEC	p27_pT198 →	+0.126	+3.000	.042	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Acetyl-a-Tubulin-Lys40 by C11orf86 expression — UCEC

Explore this box plot interactively →