C11orf80

Across TCGA patient cohorts, C11orf80 mutation is significantly associated with the RNA expression of many other genes, with 1,289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf80-associated genes across cancer lineages are IL21, KCNMA1-AS2, and RNU6-416P. Each is linked with C11orf80 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf80-to-partner and partner-to-C11orf80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by C11orf80-low versus C11orf80-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf80→partner) and Y-score (partner→C11orf80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL21 →	+0.465	+3.819	<.001	.005	3	2
COAD	KCNMA1-AS2 →	+0.271	+4.251	<.001	.008	3	2
COAD	RNU6-416P →	+0.219	+4.917	.001	.003	3	2
SKCM	RNU6-752P →	+0.246	+4.797	<.001	.003	3	2
SKCM	MIR4510 →	+0.234	+5.485	<.001	.001	3	2
LUSC	DAZ3 →	+0.029	+6.578	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,289 associations by consensus.

IL21 by C11orf80 expression — COAD

Explore this box plot interactively →