C11orf80

Across TCGA pan-cancer cohorts, C11orf80 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C11orf80’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C11orf80 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C11orf80 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

THCA, LUAD, and BLCA are the cancer types where C11orf80 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C11orf80 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.572	<.001	11	view →
LUAD	Male	III,IV	+1.500	<.001	11	view →
BLCA	Male	All	+1.475	<.001	11	view →
KIRC	All	III,IV	−0.716	<.001	11	view →
HNSC	All	III,IV	+0.679	<.001	10	view →
LIHC	Female	II,III,IV	+1.183	<.001	9	view →
LUSC	Male	All	+1.009	<.001	9	view →
KICH	Male	II,III,IV	−0.799	<.001	7	view →
BRCA	All	III,IV	+0.946	<.001	6	view →
CHOL	Male	All	+3.511	<.001	5	view →
PRAD	All	All	+0.534	<.001	2	view →
COAD	Male	All	+0.391	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C11orf80–THCA

Open the THCA breakdown →