C11orf80

Across TCGA patient cohorts, C11orf80 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf80-associated genes across cancer lineages are 14-3-3_beta, GATA6, and Heregulin. Each is linked with C11orf80 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf80-to-partner and partner-to-C11orf80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C11orf80-low versus C11orf80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf80→partner) and Y-score (partner→C11orf80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.159	-3.571	.001	.002	3	1
UCEC	GATA6 →	-0.160	-3.000	.032	.035	3	1
UCEC	Heregulin →	-0.174	-3.000	.003	.036	3	1
UCEC	Mre11 →	-0.121	-2.459	.003	.020	3	1
UCEC	P-Cadherin →	-0.200	-3.571	.004	.002	3	1
UCEC	PCNA →	+0.209	+3.169	.045	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by C11orf80 expression — UCEC

Explore this box plot interactively →