C11orf58

Across TCGA patient cohorts, C11orf58 mutation is significantly associated with the RNA expression of many other genes, with 576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf58-associated genes across cancer lineages are OR12D1, TPT1P11, and RNU6-667P. Each is linked with C11orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf58-to-partner and partner-to-C11orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D1 grouped by C11orf58-low versus C11orf58-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf58→partner) and Y-score (partner→C11orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR12D1 →	+0.095	+5.788	<.001	.003	3	2
CESC	TPT1P11 →	+0.114	+5.418	<.001	.005	3	2
CESC	RNU6-667P →	+0.402	+5.418	<.001	.005	3	2
CESC	RN7SL261P →	+0.184	+5.010	<.001	.009	3	2
BRCA	RN7SL810P →	+0.162	+5.540	.001	.004	3	2
BRCA	POLR2DP2 →	+0.115	+6.064	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 576 associations by consensus.

OR12D1 by C11orf58 expression — BLCA

Explore this box plot interactively →