C11orf1

Across TCGA patient cohorts, C11orf1 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C11orf1-associated genes across cancer lineages are MIR6089, RNU6-466P, and OR7E18P. Each is linked with C11orf1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C11orf1-to-partner and partner-to-C11orf1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6089 grouped by C11orf1-low versus C11orf1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf1→partner) and Y-score (partner→C11orf1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6089 →	+0.515	+3.937	<.001	.001	3	2
UCEC	RNU6-466P →	+0.373	+2.755	.004	.009	3	2
SKCM	OR7E18P →	+0.052	+4.513	<.001	.009	3	1
SKCM	OR51I2 →	+0.061	+4.867	<.001	.005	3	1
SKCM	SMIM7P1 →	+0.161	+6.219	<.001	<.001	3	1
SKCM	RNU6-227P →	+0.308	+5.080	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

MIR6089 by C11orf1 expression — UCEC

Explore this box plot interactively →