C10orf88

Across TCGA patient cohorts, C10orf88 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C10orf88-associated genes across cancer lineages are FASN, Cyclin-E2, and 14-3-3_beta. Each is linked with C10orf88 in more than 1 cancer types. Because this analysis shows association rather than direction, both C10orf88-to-partner and partner-to-C10orf88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by C10orf88-low versus C10orf88-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C10orf88→partner) and Y-score (partner→C10orf88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.353	+3.321	.034	.010	3	2
UCEC	Cyclin-E2 →	+0.157	+2.179	.027	.034	3	2
UCEC	14-3-3_beta →	-0.099	-2.295	.019	.033	3	1
UCEC	eIF4G →	+0.284	+1.700	.031	.044	3	1
UCEC	ACC1 →	+0.312	+2.820	.043	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-3.321	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FASN by C10orf88 expression — UCEC

Explore this box plot interactively →