BZW2

Across TCGA patient cohorts, BZW2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BZW2-associated genes across cancer lineages are Notch1, Src_pY416, and C-Raf. Each is linked with BZW2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BZW2-to-partner and partner-to-BZW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by BZW2-low versus BZW2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BZW2→partner) and Y-score (partner→BZW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.162	+2.179	.008	.034	3	2
UCEC	Src_pY416 →	-0.275	-2.794	.008	.003	3	2
UCEC	C-Raf →	+0.178	+2.459	.004	.019	3	2
UCEC	Di-Ras3 →	-0.213	-2.807	.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.266	-3.169	.015	.018	3	1
UCEC	EGFR →	-0.212	-2.115	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by BZW2 expression — UCEC

Explore this box plot interactively →