BZW1

Across TCGA cell cohorts, BZW1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BZW1-associated genes across cancer lineages are MTRNR2L10, SLC5A5, and PDCL2. Each is linked with BZW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BZW1-to-partner and partner-to-BZW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L10 grouped by BZW1-low versus BZW1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BZW1→partner) and Y-score (partner→BZW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTRNR2L10 →	+0.016	+6.357	<.001	<.001	3	1
LARGE_INTESTINE	SLC5A5 →	+0.289	+2.938	<.001	.003	3	1
LARGE_INTESTINE	PDCL2 →	+0.159	+3.584	.003	.003	3	1
LARGE_INTESTINE	ENPP6 →	+0.032	+2.793	<.001	.002	3	1
LARGE_INTESTINE	CFAP47 →	+0.276	+4.131	<.001	<.001	3	1
LARGE_INTESTINE	ZBTB21 →	+0.726	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MTRNR2L10 by BZW1 expression — CNS

Explore this box plot interactively →