BUB1B

Across TCGA pan-cancer cohorts, BUB1B Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated BUB1B data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher BUB1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BUB1B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, ESCA, and COAD are the cancer types where BUB1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.272	0.885	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.151	0.525	.005	12	view →
COAD	OS	Median	All	0.172	0.870	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
GBM	DFS	Median	All	0.052	0.257	.002	6	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
UCEC	DFS	Median	II,III,IV	0.906	0.307	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

BUB1B–KIRP (OS)

Open the KIRP breakdown →