BUB1B

Across TCGA pan-cancer cohorts, BUB1B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BUB1B data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BUB1B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BUB1B expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where BUB1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	1.000	0.639	.007	21	view →
PDAC	OS	Median	All	0.464	0.984	.005	21	view →
CCRCC	OS	Median	II,III,IV	0.668	1.000	.002	17	view →
UCEC	OS	Median	III,IV	1.000	0.433	.007	16	view →
HNSC	OS	Median	All	0.347	1.000	.008	16	view →
LUAD	DFS	Tertile	All	0.394	0.871	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BUB1B–LSCC (OS)

Open the LSCC breakdown →