BUB1B-PAK6

Across TCGA pan-cancer cohorts, BUB1B-PAK6 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated BUB1B-PAK6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BUB1B-PAK6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated BUB1B-PAK6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUSC show a favorable association.

HNSC, COAD, and BRCA are the cancer types where BUB1B-PAK6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.487	0.279	<.001	108	view →
COAD	DFS	Tertile	All	0.638	0.828	<.001	106	view →
BRCA	DFS	Median	All	0.405	0.603	<.001	59	view →
MESO	OS	Tertile	IV	0.056	0.640	<.001	51	view →
SKCM	OS	Tertile	II,III,IV	0.639	0.761	.002	33	view →
KIRP	DFS	Tertile	II,III,IV	0.162	0.703	.012	30	view →
LUSC	OS	Quartile	II,III,IV	0.754	0.304	.015	21	view →
ACC	DFS	Quartile	III,IV	0.795	0.117	.008	17	view →
UVM	OS	Quartile	All	0.104	0.841	<.001	12	view →
KIRC	DFS	Tertile	IV	0.314	0.657	.030	12	view →
STAD	OS	Quartile	IV	0.203	0.822	.003	12	view →
BLCA	DFS	Median	III,IV	0.408	0.244	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

BUB1B-PAK6–HNSC (DFS)

Open the HNSC breakdown →