BUB1B-PAK6

Across TCGA pan-cancer cohorts, BUB1B-PAK6 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of BUB1B-PAK6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BUB1B-PAK6 RNA is repressed in tumor relative to normal tissue. In most cancer types BUB1B-PAK6 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where BUB1B-PAK6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BUB1B-PAK6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.016	<.001	12	view →
KIRP	All	All	−0.014	<.001	7	view →
LUSC	Male	II,III,IV	+0.060	<.001	6	view →
READ	Male	All	+0.030	.039	3	view →
LUAD	All	All	+0.021	.030	2	view →
COAD	All	All	+0.005	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

BUB1B-PAK6–KIRC

Open the KIRC breakdown →