BUB1

Across TCGA patient cohorts, BUB1 mutation is significantly associated with the RNA expression of many other genes, with 2,339 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUB1-associated genes across cancer lineages are SSXP9, ZFYVE19, and RCC1. Each is linked with BUB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BUB1-to-partner and partner-to-BUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSXP9 grouped by BUB1-low versus BUB1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1→partner) and Y-score (partner→BUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SSXP9 →	+0.180	+4.969	<.001	.004	3	3
UCEC	ZFYVE19 →	+0.352	+2.194	.001	.001	3	3
UCEC	RCC1 →	+0.539	+4.180	<.001	<.001	3	3
UCEC	DHDDS →	+0.343	+2.389	<.001	<.001	3	3
UCEC	PIMREG →	+0.628	+1.799	.002	.001	3	3
UCEC	UBAC1 →	+0.296	+2.436	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,339 associations by consensus.

SSXP9 by BUB1 expression — CESC

Explore this box plot interactively →