BTK

Across TCGA cell cohorts, BTK mutation is significantly associated with the mutation status of many other genes, with 2,738 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTK-associated genes across cancer lineages are KIF7, WDR91, and CACHD1. Each is linked with BTK in more than 3 cancer types. Because this analysis shows association rather than direction, both BTK-to-partner and partner-to-BTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF7 grouped by BTK-low versus BTK-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTK→partner) and Y-score (partner→BTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIF7 →	+3.232	+3.523	.006	.006	1	4
LARGE_INTESTINE	WDR91 →	+2.367	+3.372	.002	.002	1	4
LARGE_INTESTINE	CACHD1 →	+2.630	+3.047	.005	.005	1	4
LARGE_INTESTINE	CPS1 →	+1.951	+3.015	.006	.006	1	4
OVARY	SMARCA1 →	+5.415	+5.415	.004	.004	1	3
OVARY	ADAM2 →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,738 associations by consensus.

KIF7 by BTK expression — BLOOD_Lymphoma

Explore this box plot interactively →