BTD

Across TCGA cell cohorts, BTD mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible BTD-associated genes across cancer lineages are SERPINA4, SERPINA7, and FSHB. Each is linked with BTD in more than 1 cancer types. Because this analysis shows association rather than direction, both BTD-to-partner and partner-to-BTD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA4 grouped by BTD-low versus BTD-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTD→partner) and Y-score (partner→BTD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SERPINA4 →	+0.013	+4.807	<.001	.006	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FSHB →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2M2 →	+0.033	+4.807	<.001	.006	3	1
LARGE_INTESTINE	TNP1 →	+0.128	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SERPINA4 by BTD expression — BLOOD_Myeloma

Explore this box plot interactively →